Fritz

Ever since the last Coronavirus epidemic caused by SARS-CoV-1, plans and tools for the containment of epidemics are being developed. However, an appropriate early warning system for local health authorities addressing this need on a regional, targeted level is not available. In the current SARS-CoV-2 pandemic, the need for such a system becomes increasingly obvious. The heterogeneity of different regions and localized outbreaks require a locally adapted monitoring and evaluation of infection dynamics.

Early recognition of an emerging epidemic is a crucial part of a successful intervention. The comparison of Germany to other European nations illustrates how crucial a timely implementation of non-pharmaceutical interventions is for the containment of an epidemic. Hence, continuous monitoring of infection processes is indispensable. For strategic planning of political interventions, epidemiological modelling and scenario calculations for forecasting and evaluation of interventions and scenarios have shown their importance. The accuracy of such forecasts largely depends on the robustness and broadness of the underlying data. Further, there is a need for an intelligible presentation of often complex simulation results without oversimplification of their interpretation and inherent uncertainty.

In this proposal, we develop a platform that integrates data streams from various sources in a privacy preserving manner. For their analysis, a variety of methods from machine learning to epidemiological modeling are employed to detect local outbreaks early on and enable an evaluation for different assumptions and on different scales. These models will be integrated into automatized workflows and presented in an interactive web application with custom scenario simulations. The platform will be based on insights gained by retrospective and prospective evaluation of the COVID-19 pandemic, using SARS-CoV-2 as a blueprint for the prevention and containment of future respiratory virus epidemics. The platform will be transferred to the Academy for Public Health Services and optimized in pilot projects with selected local health authorities under real-world conditions.

Funding Body

Funding Body

Helmholtz-Gemeinschaft e.V.; Impuls- und Vernetzungsfonds

Partner

Project Partner

Helmholtz-Zentrum für Infektionsforschung (HZI)

Helmholtz-Zentrum für Infektionsforschung (HZI)

Project Partner

Deutsches Zentrum für Luft- und Raumfahrt (DLR)

Deutsches Zentrum für Luft- und Raumfahrt (DLR)

Project Partner

Forschungszentrum Jülich

Forschungszentrum Jülich

Project Partner

Helmholtz-Zentrum für Umweltforschung (UFZ)

Helmholtz-Zentrum für Umweltforschung (UFZ)

Genetic data is highly privacy sensitive information and therefore is protected under stringent legal regulations, making them burdensome to share. However, leveraging genetic information bears great potential in diagnosis and treatment of diseases and is essential for personalized medicine to become a reality. While privacy preserving mechanisms have been introduced, they either pose significant overheads or fail to fully protect the privacy of sensitive patient data. This reduces the ability to share data with the research community which hinders scientific discovery as well as reproducibility of results. Hence, we propose a different approach using synthetic data sets that share the properties of patient data sets while respecting the privacy. We achieve this by leveraging the latest advances in generative modeling to synthesize virtual cohorts. Such synthetic data can be analyzed with established tool chains, repeated access does not affect the privacy budget and can even be shared openly with the research community. While generative modeling of high dimensional data like genetic data has been prohibitive, latest developments in deep generative models have shown a series of success stories on a wide range of domains. The project will provide tools for generative modeling of genetic data as well as insights into the long-term perspective of this technology to address open domain problems. The approaches will be validated against existing analysis that are not privacy preserving. We will closely collaborate with the scientific community and propose guidelines how to deploy and experiment with approaches that are practical in the overall process of scientific discovery. This unique project will be the first to allow the generation of synthetic high-dimensional genomic information to boost privacy compliant data sharing in the medical community.

Funding Body

Funding Body

Helmholtz-Gemeinschaft e.V.; Impuls- und Vernetzungsfonds

Partner

Project Partner

Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE)

To solve future grand challenges, data, computational power and analytics expertise need to be brought together at unprecedented scale. The need for data has become even larger in the context of recent advances in machine learning. Therefore, data-centric digital systems commonly exhibit a strong tendency towards centralized structures. While data centralization can greatly facilitate analy-sis, it also comes with several intrinsic disadvantages and threats not only from a technical but more importantly also from a legal, political and ethical perspective. Rooting in sophisticated security or trust requirements, overcoming these issues is cumbersome and time consuming. As a consequence, many research projects are substantially hindered, fail or are simply not addressed. In this interdisci-plinary project we aim at facilitating the implementation of decentralized, cooperative data analytics architectures within and beyond Helmholtz by addressing the most relevant issues in such scenarios.

Trustworthy Federated Data Analytics (TFDA) will facilitate bringing the algorithms to the data in a trustworthy and regulatory compliant way instead of going a data-centric way. TFDA will address the technical, methodical and legal aspects when ensuring trustworthiness of analysis and transparency regarding the analysis in- and outputs without violating privacy constraints. To demonstrate applica-bility and to ensure the adaptability of the methodological concepts, we will validate our develop-ments in the use case “Federated radiation therapy study” (Health) before disseminating the results.

Funding Body

Funding Body

Helmholtz-Gemeinschaft e.V. Impuls- und Vernetzungsfonds

Partner

Project Partner

Deutsches Krebsforschungszentrum (DKFZ)